L-Asparaginase induced thrombosis in acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Transient hyperthyroidism following L-asparaginase therapy for acute lymphoblastic leukemia.
The effect of L-asparaginase on the thyroid gland has not been well documented. We report the first two cases of hyperthyroidism associated with thyroid nodule following L-asparaginase therapy for acute lymphoblastic leukemia (ALL). The thyroid function abnormalities were not severe, short-lived and did not require specific therapy.
متن کاملL-asparaginase induced hyperlipidaemia in acute lymphoblastic leukaemia.
OBJECTIVE To evaluate hyperlipidaemia in patients with acute lymphoblastic leukaemia (ALL) receiving L-asparaginase. METHODS A case-control study carried out between October 2007 and October 2010 with 77 patients undergoing chemotherapy at a teaching children's hospital in Babol, Iran. Patients were treated with anti-leukaemic agents according to the protocols for standard-risk and high-risk ...
متن کاملManagement of L-asparaginase induced prothrombotic state in acute lymphoblastic leukemia.
in their report Inefficacy of fresh frozen plasma in the treatment of L-asparaginase induced coagulation factor deficiencies during ALL induction therapy, Nowak-Göttl and coll. reported that the prophylactic administration of fresh frozen plasma in acute lymphoblastic leukemia (ALL) patients treated with L-asparaginase (L-Ase) is of no use in correcting the hemostatic imbalance. In fact, they o...
متن کاملCharacterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma.
Plasma lipids and apolipoproteins were determined in 19 children with acute lymphoblastic leukemia (ALL) or malignant lymphoma (ML) who were treated by L-asparaginase with prednisolone and vincristine. Extreme hypertriglyceridemia, i.e., over 10,000 mg/l of the maximum serum triglyceride concentration, was induced in 8 patients; these concentrations were not over 10,000 mg/l in the remaining 11...
متن کاملUse of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group.
L-asparaginase is a hydrolase that catalyzes the conversion of L-asparagine--an endogenous amino acid necessary for the function of some neoplastic cells, such as lymphoblasts. In most human cells deficiency of L-asparagine can be compensated by alternative synthesis pathway through which L-asparagine is produced from aspartic acid and glutamine by asparagine synthethase. Depletion of L-asparag...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Pharmacotherapeutics
سال: 2012
ISSN: 0976-500X
DOI: 10.4103/0976-500x.99449